文学军
姓 名：文学军 学 历：博士
职 称：教授
联系方式：xuejwen@gmail.com；
个人简介
文学军，男，博士，教授，博士生导师。2003年美国犹他大学(University of Utah)生物工程系(Department of Bioengineering)博士毕业后留美在世界生物材料研究发源地美国克莱姆森大学(Clemson University)任终身制教席 (Tenure-Track faculty)，任教4年后(2008年)获得美国终身席教职(Faculty with Tenure)，2年后(2010年)，升为正教授和南卡州政府命名的Hansjörg Wyss冠名首席终身席正教授（Hansjörg Wyss Endowed Chair Professor）。2003年创建了“克莱姆森大学和南卡医科大学联合生物医学工程中心(Joint Bioengineering Program between Clemson University and Medical University of South Carolina)”。2012年起为美国弗吉尼亚医学院/弗吉尼亚联邦大学(Medical College of Virginia/Virginia Commonwealth University)的William Goodwin冠名首席终身席正教授（William Goodwin Endowed Chair Professor），任该校生物制造实验室主任，再生医学实验室主任。主持和参与40多科研项目，总经费超过4700 万美元。文学军教授是美国医学与生物工程院（American Institute for Medical and Biological Engineering，AIMBE）的Fellow（2012年当选）和美国国家发明家科学院（National Academy of Inventors， NAI）的Fellow。带领团队在全合成生物材料、天然改性生物材料、可注射型水凝胶等在骨骼系统、神经系统、心血管系统、呼吸系统、消化肝胆系统、泌尿系统、内分泌系统、口腔科、眼科、肿瘤科、妇产科、感染科、影像科、介入科、等方面的应用以及3D打印人工器官等方面在《柳叶刀 The Lancet》、《Progress in Polymer Science》、《Advanced Functional Materials》、《Biomaterials》、《Advanced healthcare Materials》、《Biofabrication》、《ACS Appl Mater Interfaces》、《FASEB Journal》、《Journal of Neuroscience》、等著名学术期刊上发表160多篇论文。
研究方向
从事生物医学工程、干细胞、组织工程、再生医学、生物材料、医疗器械、纳米医学、和三维生物打印等研究。
科研项目(部分)
1．Hansjörg Wyss基金会：Research in Regenerative Medicine，4,000,000美元，2010.8.1-2012.7.31，第一负责人
2．William Goodwin基金会：Research in Engineering and Medicine，3,000,000美元, 2012.8.1-2018.7.31，第一负责人
3．美国国立卫生研究院(National Institutes of Health, NIH)科研项目：Antimicrobial catheters with cell and tissue compatibility，1,484,415美元, 2016.6.1-2021.5.31，第一负责人
4．美国国立卫生研究院(National Institutes of Health, NIH)科研项目：Combination of hiPSCs and bioengineering to repair injured pediatric brain，2,020,000美元, 2016.6.1-2021.5.31，第一负责人
5．美国国立卫生研究院(National Institutes of Health, NIH)科研项目：Antimicrobial and Biocompatible Endotracheal Tubes, 1,725,000美元美元, 2018.3.1-2020.8.31，第一负责人
6．Virginia Biosciences Health Research Corporation科研项目：Bioengineering for the therapeutic delivery of islet derived human beta-cells massively expanded using Propagenix technology，425,000美元, 2017.4.1-2018.9.30，第一负责人
7．美国国立卫生研究院(National Institutes of Health, NIH)科研项目：Antimicrobial catheters with and low protein and cell adhesion，234,068美元, 2015.7.1-2016.6.30，第一负责人
8. 美国国立卫生研究院(National Institutes of Health, NIH)科研项目：RFID based Wireless System for Self-powered Implantable Pediatric Cardiac Sensors，402,941美元, 2016.5.1-2018.4.30，第一负责人
9．中国自然科学基金面上项目；生物活性可注射水凝胶促进脑卒中区网络化血管结构重建与神经再生的研究，650,000人民币, 2012.3.1-2015.3.1，第一负责人
10．美国国家科学基金项目(National Science Foundation, NSF)CAREER: A novel space-creation concept to enhance the survival of transplanted human stem cells一种用于提高移植的人干细胞存活率的新的空间创建理念，436,189美元，2008.8.1-2014.7.31, 第一负责人
发表论文(部分)
1.Zhao, P., Chen, Q., Lin, C., Lin, Z., Chang, L., Shao, X., Li, Y., Zhang, J., Fan, Z., & Wen, X. Infection prevention with natural protein-based coating on the surface of Foley catheters: a randomised controlled clinical trial. The Lancet, 2016. 388: S7.
2.Ram Kuwar, Ning Zhang, Adam McQuiston, Xuejun Wen, Dong Sun; Generation of induced pluripotent stem cells from rat fibroblasts and optimization of its differentiation into mature functional neurons; Journal of Neuroscience Methods; 406, June 2024, 110114; https://doi.org/10.1016/j.jneumeth.2024.110114
3.Honglei Yin, Zhuxin Sui, Yutong Wang, Dechen Liu, Qinglu Wang, Yanchao Wang, Lei Sun, Jinfeng Li, Zhen Li, Yue Liu, Shang Guo, Wenwen Wang, Hongtao Yin, Ping Liu, Kezhong Zhang, Huaibo Zhang, Yajun Liu, Yanqiu Liu, Qiqi Zhou, Dianfang Wei, Hui Zhang, Shanshan Wang, Yaochao Ning, Shuang Geng, Xuejun Wen, Youping Deng, Hongwei Wang, Yunliang Wang; The efficacy and safety of NeuroWell antidepressant dietary supplement, Deanxit, and their combination in the treatment of mild-to-moderate depression: A randomized clinical trial; Genes & Diseases; 2024, In press; https://doi.org/10.1016/j.gendis.2023.101171.
4.Vince Beachley, Jonathan Kuo, Vladimir Kasyanov, Vladimir Mironov, Xuejun Wen; Biomimetic crimped/aligned microstructure to optimize the mechanics of fibrous hybrid materials for compliant vascular grafts; Journal of the Mechanical Behavior of Biomedical Materials; 150, 2024, 106301, https://doi.org/10.1016/j.jmbbm.2023.106301.
5.Kun Fu , Lei-Lei Yang, Ning Gao, Pengbi Liu, Bo Xue, Wei He, Weiliu Qiu, Xuejun Wen; Modified Five Times Simulated Body Fluid for Efficient Biomimetic Mineralization. Heliyon; Accepted; http://dx.doi.org/10.2139/ssrn.4724506
6.Wanqing Ji, Zhiru Wu, Jiaming Wen, Hengxin Tang, Zhuopeng Chen, Bo Xue, Zhenming Tian, Yueyang Ba, Ning Zhang, Xuejun Wen & Bo Hou. A simple method to isolate structurally and chemically intact brain vascular basement membrane for neural regeneration following traumatic brain injury. Biomater Res (2023), 27, 2
7.Ram Kuwar, Xuejun Wen, Ning Zhang, Dong Sun. Integrin binding peptides facilitate growth and interconnected vascular-like network formation of rat primary cortical vascular endothelial cells in vitro. Neural Regen Res. 2023 May;18(5):1052-1056
8.Min Liu, Zhiqiang Han, Yong Zhi, Yetian Ruan, Guangxu Cao, Guangxue Wang, Xinxin Xu, Jianbing Mu, Jiuhong Kang, Fangping Dai, Xuejun Wen, Qingfeng Zhang, Fang Li. Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer. Translational Research, (2023) 253, 80-94.
9.Linyan Duan, Xingfan Li, Rong Ji, Zhizhong Hao, Mingyue Kong, Xuejun Wen, Fangxia Guan, Shanshan Ma; Nanoparticle-Based Drug Delivery Systems: An Inspiring Therapeutic Strategy for Neurodegenerative Diseases; Polymers (Basel). 2023 May 5;15(9):2196. doi: 10.3390/polym15092196.
10.Guangxu Cao, Jiali Yue, Yetian Ruan, Ya Han, Yong Zhi, Jianqiao Lu, Min Liu, Xinxin Xu, Jin Wang, Quan Gu, Xuejun Wen, Jinli Gao, Qingfeng Zhang, Jiuhong Kang, Chenfei Wang, Fang Li; Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment; EMBO J. 2023;42(16):e110757. doi: 10.15252/embj.2022110757
11.Weifeng Zhang, Ting Wang, Ruixue Guo, Wen Cui, Wei Yu, Zhihui Wang, Yumin Jiang, Minghan Jiang, Xiaojie Wang, Chao Liu, Jing Xiao, Jin Shang, Xuejun Wen and Zhanzheng Zhao； Variation of Serum Uric Acid Is Associated With Gut Microbiota in Patients With Diabetes Mellitus. Frontiers in Cellular and Infection Microbiology, 2022, 11, 761757
12.Xingfan Li, Linyan Duan, Mingyue Kong, Xuejun Wen, Fangxia Guan and Shanshan Ma; Applications and Mechanisms of Stimuli-Responsive Hydrogels in Traumatic Brain Injury. Gels. 2022; 8(8):482
13.Bo Xue, Xuejun Wen, Ram Kuwar, Dong Sun, Ning Zhang. Age-dependent viscoelastic characterization of rat brain cortex. Brain Multiphysics, 2022; 3, 100056.
14.Shaocheng Wang, Siyong Lin, Bo Xue, Chenyu Wang, Nana Yan, Yueyan Guan, Yuntao Hu, Xuejun Wen; Bruch’s-Mimetic Nanofibrous Membranes Functionalized with the Integrin-Binding Peptides as a Promising Approach for Human Retinal Pigment Epithelium Cell Transplantation. Molecules. 2022; 27(4):1429
15.Julong Chen, Xuejun Wen, Shuo Zhang; The mechanism of the interaction between the formed emulsification and yeast cells in biotransformation system; Journal of Chemical Technology & Biotechnology. (2022), 97(1), 199-207
16.Shanshan Ma, Jiankang Zhou, Tuanjie Huang, Zhenkun Zhang, Qu Xing, Xinkui Zhou, Kun Zhang, Minghao Yao, Tian Cheng, Xiaofeng Wang, Xuejun Wen, Fangxia Guan. Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury. Acta Biomater. 2021; 131:185-197. doi: 10.1016/j.actbio.2021.06.038.
17.Xiaolie He, Yanjing Zhu, Li Yang, Zhaojie Wang, Zekun Wang, Jianhao Feng, Xuejun Wen, Liming Cheng, Rongrong Zhu. MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells. Adv Sci (Weinh) 2021 05 25;8(9):2003535
18.Julong Chen, Xuejun Wen, Shuo Zhang, Shuo. The mechanism of the interaction between the formed emulsification and yeast cells in biotransformation system. Journal of Chemical Technology & Biotechnology. 2021, 97. 10.1002/jctb.6929.
19.Juan Liu, Yuhua Yu, Jie Zhao, Peng Zhao, Xuejun Wen, Zhigang Zhuang, & Chao Lin,. Integrating disulfides into a polyethylenimine gene carrier selectively boosts significant transfection activity in lung tissue enabling robust IL-12 gene therapy against metastatic lung cancers. Materials Science and Engineering: C. 2021, 128. 112358. 10.1016/j.msec.2021.112358.
20.Shuo Zhang, Zhuoyue Xu, Xuejun Wen, Changzheng Wei. A nano chitosan membrane barrier prepared via Nanospider technology with non-toxic solvent for peritoneal adhesions’ prevention. Journal of Biomaterials Applications. 2021, 36. 088532822110081. 10.1177/08853282211008109.21.Pengbi Liu, Xiaomei Zeng, Xuejun Wen. Design and Synthesis of New Cationic Antimicrobial Peptides with Low Cytotoxicity. International Journal of Peptide Research and Therapeutics. 2021 27. 1-10. 10.1007/s10989-020-10133-4.
22.Tianci Jiang, Lingling Dai, Pengfei Li, Junwei Zhao, Xi Wang, Lin An, Meng Liu, Shujun Wu, Yu Wang, Youmei Peng, Di Sun, Caopei Zheng, Tingting Wang, Xuejun Wen, Zhe Cheng. Lipid metabolism and identification of biomarkers in asthma by lipidomic analysis. Biochim Biophys Acta Mol Cell Biol Lipids 2021 02 4;1866(2):158853
23.Ling-Xiao Deng, Nai-Kui Liu, Ryan Ning Wen, Shuang-Ni Yang, Xuejun Wen, Xiao-Ming Xu. Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal cord hemisection. Neural Regen Res 2021 Jan;16(1):186-191
24.Chong Lian, Lei Zhao, Jiacong Qiu, Yang Wang, Rencong Chen, Zhen Liu, Jin Cui, Xiaonan Zhu, Xuejun Wen, Shenming Wang, and Jinsong Wang; miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation; Aging (Albany NY). 2020; 12(22): 22599–22613
25.Wanqing Jia, Bo Hou, Weige Lin, Linli Wang, Wenhan Zheng, Weidong Li, Jie Zheng, Xuejun Wen, Ping He; 3D Bioprinting a human iPSC-derived MSC-loaded scaffold for repair of the uterine endometrium; Acta Biomaterialia; 2020; 116, 268-284
26.Qianxin He, Lu Wen, Luyao Wang, Ya Zhang, Wei Yu, Fanliang Zhang, Weifeng Zhang, Jing Xiao, Xuejun Wen, Zhanzheng Zhao; miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats; Ren Fail; 2020; 42(1): 932-943
27.Wei Hongliang, Weikun Li, Hongli Chen, Xuejun Wen, Juan He, Jingjing Li; Simultaneous Diels-Alder click reaction and starch hydrogel microsphere production via spray drying; Carbohydrate Polymers; 2020;241:116351
28.Ram Kuwar, Xuejun Wen, Ning Zhang, Dong Sun; An integrin-binding array platform identifies αvβ8 and α5β1 integrins on rat primary cortical neurons to support their survival and growth; J Neurosci Methods; 2020; 339:108729
29.Fei Han, Peng Zhang, Tianwu Chen, Chao Lin, Xuejun Wen, Peng Zhao; A LbL-Assembled Bioactive Coating Modified Nanofibrous Membrane for Rapid Tendon-Bone Healing in ACL Reconstruction; Int J Nanomedicine; 2019; 14:9159-9172. doi: 10.2147/IJN.S214359
30.Han F, Zhang P, Wen X, Lin C, Zhao P. Bioactive LbL-assembled multilayer nanofilms upregulate tenogenesis and angiogenesis enabling robust healing of degenerative rotator cuff tendons in vivo. Biomater Sci; 2019; 7(10); 4388-4398; doi: 10.1039/C9BM00413K